الفهرس 
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Abstract
The aim of the present work is to study the role of RAA system in pathogenesis of sodium and water retention and renal functional , fimpairement in liver cirrhosis. Also, to study the effects of sympathetic ” I., i stimulation and calcium on the degree of activity ofRAA system and on i the renal functions in these cases. This study was performed in 2.~ parts; A) included 56 cirrhotic (6 patients with compensated cirrhosis and 50 with ’: decompensated liver cirrhosis and ascites). The PRA, plasma aldosterone concentration, and renal functions were determined in them before and after therapy with captopril, propranolol, and nifedipine. B) experimental part, included 50 rats in which liver cirrhosis was induced by CCl4 injections. The PRA, PAC, and renal functions were determined before and after therapy with the above mentioned drugs. It has been found that renin and aldosterone levels are increased in cirrhotics with ascites, but their levels are nearly normal in those with compensated cirrhosis. There was a strong negative correlation between decreased serum albumin level and increased RAA system activity. The correlation between increased RAA system activity and decreased albumin is not linear in all cases, Captopril administration induced a significant decrease in the RAA system activity in cases of liver cirrhosis with ascites with resultant increase in sodium and water excretion. Propranolol therapy also induced a significant decrease in PRA and PAC with subsequent improvement in renal sodium and water handling. This effect still present when propranolol was added to spironolactone. Nifedipine therapy did not