الفهرس 
Methods of MicroencapsulationOnly 14 pages are availabe for public view
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Abstract
In this thesis we studied the encapsulation of brilliant blue as a model of low molecular weight drugs, within polymeric beads of alginate hardened with calcium chloride and/or chitosan to prolong and targeting the release of drugs to a specific site. The thesis comprises three main chapters: The first chapter: Included a large scope on application of the microencapsulation in many technological fields. We focused our study on the encapsulation of drugs to form a drug delivery system, which offers advantages over the conventional therapy. The second chapter: Dealt with the experimental part. It included the preparation and characterization of calcium alginate beads and alginate/chitosan beads. The third chapter: Showed the obtained results and their interpretation and it can be divided into two separate sections (A) and (B). For Calcium Alginate Beads: The optimum conditions for preparation of Ca-Alg beads were 2% alginate, 3% CaCl2 & curing for 30 min and the formed beads showed spherical shape with diameter 544µm. the encapsulation efficiency improved from 62% to 90% and the release could be targeted to the intestine where the beads shown Swelling in SGF = 60% however in SIF = 5000%). For Alginate/Chitosan Beads: We make a quantitative study for the interaction between alginate and Chitosan to quantify the amount of Chitosan bounded to alginate beads using different parameter like preparation method, Chitosan pHs and Chitosan concentration and we show that maximum binding between chitosan and alginate takes place at pH 4 to 5.5 and the two steps method show higher binding than the one step method. Also EE % improved from 90% to 100% and the rate of release was retarded and targeted to intestine where the beads shown Swelling in SGF = 100% however in SIF = 6500%).