الفهرس 
Introduction
Chronic reneal failureOnly 14 pages are availabe for public view
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Abstract
companion to 12 healthy persons as controls of mat gable age and sex. The study conducted in a period between July 1997 to July 1998 in the renal dialysis unit of Assiut University Hospitals .Our patients were divided into 2 groups according to the duration of dialysis
• Patients dialysed for less than) 5 years (Group A).
• Patients dialysed (or more than 5 years (Group 11).
Beside full history, clinical examination, and routine laboratory investigation serum melatonin, serum 1L- iB and serum ADA before and after HD were determined in patient with CRF as well as controls
A significant reduction in the serum melatonin in all studied groups in comparison to the controls was observed. Serum .level alter dialysis showed insignificant difference in comparison Lo the level before dialysis.
The reason for the decline in the serum level may be due to decrease in the serum level of N- acelyl transeferase (NAT) activity which is the role-limiting enzyme in melatonin biosynthesis. This may be a result of lowered B- adrenergic responsiveness in the. U
raemic patients. The non significant decline in the serum level, .of melatonin after dialysis in comparison to the level- before dialysis was due lo .the binding of g melatonin
to albumin to form a complex too large to pass through the , dialyzer membrane.
The study of 36 patients chronic kidney failure , which are treated by washing bloody frequent and aged between 26 and 70 years and also has been studied 12 people from healthy people as a control group aged between 26 and 62 years to see how the effect of the hormone melatonin and interleukin- 1 beta and enzyme adenosine Diamgniz on the immune status of patients before and after dialysis .
The patients were divided according to a washing into two groups : -
The first of them going on dialysis for a period of less than five years.
The second of them going on dialysis for more than five years.
Has yielded results of the study and a decrease substantially to the level of the hormone melatonin in the two groups for the control group , while there were no significant differences between the level after washing from its level before washing and is likely a decline in the level of the hormone melatonin to a shortage in the activity of the enzyme responsible for the composition of the hormone melatonin ( enzyme carrier to the acetyl group ) .
And also that there is no difference in level after level before washing laundry may be due to its association Balalbummen where consists compound can not force through membrane filters hemodialysis .
The study showed a rise in the level of interleukin- 1 beta in terms of substantial in patients from healthy subjects and in patients continuing on dialysis for more than five years on who the laundry for less than five years and attributed this rise to the increasing activity of white blood cells of the type Monosets which are source for this indicator and it is also considered a target also found that the level of this indicator at least after washing bloody kiss as a result lost through membrane filters.