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العنوان
Synthesis of chelating oxazole derivatives of potential biological activity /
المؤلف
Sheha, Mahmoud Mohamed.
هيئة الاعداد
باحث / محمود محمد محمد شيحة
مشرف / عادل فوزي يوسف
مناقش / رجب محمد شفيق
مناقش / محمد ياسين عبيد
الموضوع
Oxazole derivatives. pharmaceutical chemistry.
تاريخ النشر
1990.
عدد الصفحات
124 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الصيدلة
الناشر
تاريخ الإجازة
7/10/1999
مكان الإجازة
جامعة أسيوط - كلية الصيدلة - pharmaceutical Chemistery
الفهرس
Only 14 pages are availabe for public view

from 142

from 142

Abstract

Synthesis of chelating oxazole derivatives with potential biological activity.the thesis is prefaced by a survey on the biological and chelating activities of oxazole derivatives.Progressing Message study on the scientific heritage blogger for biological effects and qualities claw of derivative Alooxasul. Taking into account the design and preparation of derivatives 5 - Vinnal the Ooxasul with claw qualities. Enter the site also No. 2 - of Alooxasul ring some groups to increase the claw qualities.It has emerged that vehicles (ad) 9 does not have the ability to link minerals under the circumstances and experiences of either the rest of the vehicles (ad) -10 -13 has the ability to varying degrees appeared to link the elements copper, zinc and iron bilateral.It has been shown that the properties Amajlbeh AV (ad) 10-13 affected groups r and the properties of electronic substituent X in addition to the same item as all derivatives with different X her susceptibility to union with copper and zinc, but the Union with an iron and a clear image of the other, if that in some cases uniteHas been studying the interaction group most the components (d) 10-13 Katrayak to copper toxicity, as well as anti-inflammatory at one time, most of these has proved the effectiveness of the largest derivatives of penicillamine. Was marked compound (d) 12 remarkable degree of effectiveness.Has been studying the effectiveness of the group (ad) 9, which does not have portability of the Union with the elements as well as the group (ad) 12 which showed greater susceptibility to a union with the elements as anti-bacterial positive and Gram-negative. The first group has been shown (ad) 9 and do not have any effective as anti Group B (ad) 12 have effective against Gram-positive bacteria greater than Altaracelikan of Hedrokolorad. As it turns out that the compound (d) 12 is the most effective of these compounds against two types of bacteria, Gram-negative and positive.