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Abstract Polycystic ovarian syndrome (PCOS) is the most common cause of anovulation among women presenting with infertility. Patients show resistance to clomiphene citrate regimen has long been known to be a target for other modality of management. Laparoscopic ovarian drilling is an option. However this procedure carries a potential risk of inducing premature ovarian failure or diminished ovarian reserve. Objective: Assessment of the ovarian reserve and ovarian stromal hemodynamics before and after laparoscopic ovarian drilling. Methods: pre-operative assessment of basal serum FSH and evaluation of ovarian stromal blood flow using color Doppler flow velocities in seventy-five infertile patients with PCOS comparing results with that early and late post-operative values. Results: There were statistically significant changes in the serum concentrations of early follicular phase FSH after Laparoscopic ovarian drilling (4.4 ± 1.6 SD mIU/ml (range 2.0 –7.8 mIU/ml) before operation to 6.05 ± 1.68 SD mIU/ml (range 3.7 –10.5 mIU/ml) 6–10 weeks after operation. There was also a statistically significant decrease in peak systolic velocity (PSV) and end diastolic velocity (EDV) of ovarian stromal arteries after laparoscopic ovarian drilling (P< 0.001). RI and PI were increased although not significant statistically. Conclusion: Correlation between diminished ovarian stromal blood flow (evidenced by Doppler studies); the coincident diminished ovarian volume, antral follicle count and the increase in serum FSH might give apprehension toward a probable effect of LOD on ovarian reserve. |