الفهرس 
Scope of workOnly 14 pages are availabe for public view
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Abstract
SUPTKisitory formulations containing each of chlorpromazine HCl(CPM}, salicylamide(SA) and Azapropazonc (AlP) were prepared using different suppository bases such as Witepsols Hl;h W)) & E75 (alone or in combination willi Tweens 20, 40, 60 and 80), Emulsion and polyeihyleneglycol (PEG), The melting point, solidification point. hardness, defonnation time and release rate were studied for the formulated suppositories and two commercial brands (for comparative study in ease of CPM). The bioavailability study of SA and AlP suppositories from some selected formulations was estimated in human volunteers and RaL<:; respectively. The deformation times of the suppositories were in correlation with their melting point values. Both the solidifieation point and hardnes..”l values were within the official range. The incorporatlon of surface active agents in Witepsols lowered the physical
parameters {melting point, solidification point, hardness and deformation time) to a degree depending on the concentration added rather than the type of Tweens. CPM suppositories did not show any change in colour, drug content and physical parameters as long as they were stored in dark place at room temperature for about one year.