الفهرس | Only 14 pages are availabe for public view |
Abstract This study explain the effect of Omega -3 fatty acid on bone healing in Ginea pigs so, this study contains 48 adult male their weight 400-500 gm and divided into control group and treated group, twenty four animals at each group. Control group received the vehicle of the drug (corn oil) orally for three months and treated group received omega-3 fatty acid orally dissolved in vehicle for three months. Then, the animals of both groups were subjected to bone defect surgery in the mandible under the general anesthesia and sacrificed at 1, 3& 5 weeks respectively. Then examination after staining by Haematoxyline and Eosin stain, Masson’s trichrome, Periodic acid- Schiff. (PAS), Alkaline phosphatase and Acid phosphatase stain and this study concluded that administration of omega-3 fatty acid in guinea pigs with mandibular bone defects lead to: Regression of post surgical inflammation in comparison to control group, Enhancement in the matrix formation resulting in acceleration in the rate of bone formation. So it is recommended to use omega-3 fatty acid in treatment of alveolar bone loss as a result of periodontitis, and after any surgery result in bone defect in both jaws. |