الفهرس 
REVIEW OF LITERATUREOnly 14 pages are availabe for public view
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Abstract
Aiming to increase the biological activity of some interesting nucleosides, the presented study is directed to prepare some cytidine and inosine nucleosides concerning modification in their structures. 2`,3`-O-Isopropylidene cytidine was used as a suitable substrate for such synthesis to produce the desired cytidine derivatives. Consequently, the nucleosides were synthesized through the reaction of 5-bromo- 2`,3`-O-isopropylidenecytidine with each of ethylglycinatehydrochloride, urea, methylalanine, benzylamine and also with methanesulphonyl chloride.
Furthermore, 5-bromocytidine was reacted with maleic anhydride and cytidine was allowed to react with furfural and with 2-carboxylic thiophene. On the other side, the synthesis of some other desired compounds can also be achieved by introducing some modification in their structures, especially, in the sugar part. This route was accomplished via the synthesis of 5`-aldehyde-2`,3`-O-isopropyl-idenecytidine as intermediate. The latter compound was reacted with methylamine. Cytidine was converted into dialdhyde which was also used as intermediate to react with methyliodide. In the case of purine nucleosides 2`,3`-O-isopropylidene inosine was allowed to react with ethylglycinatehydrochloride and urea. The synthesis of 5`-aldehyde-2`,3`-O-isopropylidene inosine was performed to be used as intermediate. The latter compound was reacted with ethylglycinate-hydrochloride. On the other hand, inosine was converted into dialdhyde and was allowed to react with methyl iodide and ethylcyanoacetate. The biological activity of the prepared compounds was also described.