الفهرس | Only 14 pages are availabe for public view |
Abstract Background: Venous thromboembolic (VTE) events are being increasingly diagnosed in systemic and cerebral vessels in children. Systemic VTE are increasing in children as a result of therapeutic advances and improved clinical acumen in primary illnesses that previously caused mortality. Objectives: To review the up-to-date studies regarding the incidence, etiology of venous thrombosis in childhood, and to highlight the recent methods for diagnosis. Methods and results: The impact of thrombophilic markers on longterm therapy and outcome of children with VTE has not been completely clarified. According to the current guidelines for thrombophilia, all children with VTE should be tested for a full panel of genetic and acquired prothrombotic traits. Conclusion: Thromboembolism in a child is a serious condition that, in addition to the complications also seen in adults, may adversely affect the child’s further development. Better predictors of prognosis in relation to risk factors, therapy and prophylaxis are therefore urgently needed. |