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Abstract
The thesis comprises the following .a- Organic synthesis of some new quinoxaline derivatives.
b- Study of biochemical effect of some synthetic compounds.
a. The organic synthesis:
The project aimed to synthesis some new quinoxaline. Thus the reaction of 4-Methylphenylene-diamine 1 with a-dicarbonyls namely benzil, p-dichlorobenzil, tetraketones, 9,10-phenanthrenequinone and acenaphthenequinone resulted in cyclocondensation affording quin-oxalines 2a-g 1).
b. The biochemical effect:
In the toxicity studies, it was found that the tested compounds 4b and 4c were considered to be safe up to the dose 200 mg/kg. The most effective doses for the inhibition of Ehrlich carcinoma cell EAC growth for 4b and 4c were found 100 mg/kg. Treatment of EAC bearing mice with single and repeated doses of the tested compounds 4b and 4c was studied both single and repeated doses induced remarkable decrease by 55.5% and 49% (P < 0.001) for the tested compound 4b and 56% and 66.4% (P < 0.001) for the tested compound 4c of the viable tumor cell count compared to untreated EAC cells. These results were proved by the results obtained from the percent of change of body weight and life span prolongation of tumor bearing mice.
Determination of some biochemical parameters in serum and liver of tumor bearing mice after injection single and repeated doses of the tested compounds 4b and 4c were found as follows:
In serum:
1. Glucose :
The tested compound 4b showed high significant decrease (-41%) for the single dose and insignificant increase (+11.04%) for the repeated doses. The tested compound 4c showed high significant decrease (-54%) for the single dose and insignificant decrease (-6.2%) for the repeated doses.
2. Total protein :
The tested compound 4b showed insignificant increase (+5.7%) for the single dose and insignificant increase (+6.7%) for the repeated doses. The tested compound 4c showed significant increase (+15.4%) for the single dose and insignificant decrease (-6.7%) for the repeated doses.3. Albumin: