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Abstract
>The present study was conducted on 35 patients with CRF and 15 age and sex matched healthy controls. These patients were selected from Nephrology Unit-Internal Medicine Department, Zagazig University Hospitals. All of them were subjected to full history taking, clinical examination and laboratory investigations including urea, creatinine, creatinine clearance, total protein, albumin, fasting glucose level, lipid profile, quantitative C-reactive protein, total plasma homocysteine level, vitamin B12 and folic acid.
from this study the following results can be summerized: Twenty four patients from CRF group were suffering from CVD (68.5%).
• There was a significant increase in systolic and diastolic blood pressure in CRF group compared to control group. Twenty seven patients from CRF were hypertensive (77.1%). Hypertensive patients were 8.35 times more risky to have CVD than non-hypertensive patients (OR = 8.35, 95% CI = 1.36-65.48).
• There was a significant decrease in total protein and albumin in CRF group compared to control group.
• There was a significant increase in glucose level in CRF group compared to control group. Nineteen patients from CRF were diabetic (54.3%). Diabetic patients were 9 times more risky to have CVD than non-diabetics (OR = 9, 95% CI = 1.28-79.4).There was a significant increase in total cholesterol, triglycerides and LDL cholesterol and a highly significant decrease in HDL cholesterol in CRF group compared to control group. Twenty five patients from CRF were dyslipidemic (71.4%). Dyslipidemic patients were 8 times risky to have CVD than patients with normal lipid profile (OR = 8, 95% CI = 1.28-57.39).
• There was a highly significant increase of total Hcy in CRF group compared to control group. Twenty patients from CRF were hyperhomocysteinemic (57.4%). Hyperhomocysteinemic patients were 6.48 times more risky to have CVD than patients with normal Hcy level (OR = 6.48, 95% CI = 1.07-44.4).
• There was a highly significant increase of vitamin B12 and folic acid in CRF group compared to control group.
• There was a highly significant increase of CRP levels in CRF group compared to control group. There was a highly significant positive correlation between Hcy and both urea and creatinine and a highly significant negative correlation between Hcy and creatinine clearance in CRF group.