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Abstract
The aim of the present work is to:
1- Study the effects of oral administration of CCl4 on the liver of adult albino rats. 2- Compare between the effectiveness of DDB and Nigella Sativa oil in improvement and protection of the liver from the damage induced by CC4 in adult albino rats Alternative medicine is the hope of medical professionals and
patients to stop using drugs and chemicals, which cause a burden on the
liver to do metabolism and detoxify these agents. Herbal medicine is one
of the branches of the alternative medicine, which is widely used in last
years to deal with many diseases.
Fruits of schisandra have been traditionally used in China for the
treatment of dyspnea, cough, mouth dryness, spontaneous diaphoresis,
nocturnal diaphoresis, nocturnal enuresis, dysentery, insomnia and
amnesia. Nigella Sativa seeds have been widely used in traditional medicine
as diuretic, antihypertensive, liver tonic, digestive, emmenagogue,
analgesic, antihelmintic, anti-bacterial, and useful in skin disorders. It also has been extensively studied for its biological activities and has been shown to be anti-diabetic, anticancer, immunomodulator, spasmolytic, bronchodilator, hepatoprotective and renal protective due to its antioxidant properties.
In this work, we studied the carbon tetrachloride-induced hepatotoxicity by evaluation of liver function tests CAST, AL T and total bilirubin) and serum malondialdehyde. Liver tissue was subjected to histopathological examination using the routine Haematoxylin and Eosin stain. DDB and N.S.oil were used to counteract CCl4-induced hepato- toxicity and to compare between them to know which one is more
effective In improvement and protection against CCl4-induced liver damage.