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Abstract
Adrenomedullin (AM) was discovered from human pheochromcytoma tissue by monitoring the elevating activity of intracellular cyclic adenosine monophosphate (cAMP) in rat platelets. AM elicits multiple biological activities, among which the most characteristic one is a potent and very powerful hypotensive activity caused by dilatation of resistance vessels. A sensitive and specific radioimmunoassay revealed that AM is present in circulating blood as well as in a variety of tisssues including the kidney. The plasma AM levels are increased in renal disease. AM, therefore, seems to function as a novel system that controls circulation and body fluid and may be involved in pathophysiological changes in renal disease.
The aim of the present study was to measure plasma concentration of Adrenomedullin (AM) in patients with chronic renal failure on different modalities of treatment (conservative and haemodialysis) and correlate their level with mean arterial blood pressure.
This study was conducted on the 40 subjects. They were divided into 3 groups:
1-Control group:
This group comprised 10 subjects; 5 females and 5 males, matched for age and sex as control.
2-Chronic renal failure patients on hemodialysis:
It included 20 patients with CRF on hemodialysis, 9 males and 11 females with exclusion of heart failure, lung disease, septicaemia and atherosclerosis.
3-Chronic renal failure on conservative treatment:
It included 10 patients with impaired renal failure (IRF) on conservative treatment; 4 males and 6 females matched for age and sex, all with exclusion criteria of group 2.