الفهرس Only 14 pages are availabe for public view
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Abstract
Experimental models in neurosurgery are animal models that modulated to be similar to nervous system injuries and diseases which enable us to find out pathogenesis and possible ways of management of these lesions. Experimental model use in neurosurgery started in the early beginning of 20th century after appearance of new modalities in imaging and histopathological stains which make it easier for researchers to follow the progress of the lesions. Experimental models are classified into:
1- Induced models.
2- Spontaneous models.
3- Transgenic models.
4- Orphan models.
5- Negative models.
Experimental models are carefully selected and in need for special housing regarding cages, lightening, ventilation and special infection prevention system. Experimental models in congenital anomalies include hydrocephalus and syringomyelia. Experimental models in traumatology include brain and spinal cord injuries. Experimental models of vascular disorders include cerebral aneurysm, cerebral vasospasm and cerebral ischemia. Experimental models of CNS infection include viral infection, brain abscesses, fungal infection and meningitis. Experimental models in oncology include gliomas, brainstem tumors, medulloblastoma and metastasis. Experimental models of functional neurosurgery include Parkinson’s disease and Huntington’s disease. Experimental research in tissue culture and gene therapy is considered. Although experimental models have a wide range of use in neurosurgery, they have a lot of scientific problems.