الفهرس 
regulation of renal blood flowOnly 14 pages are availabe for public view
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Abstract
Urinary tract obstruction is a common health problem. Obstructive nephropathy can be manifested clinically as a sudden or gradual and insidious decrease in renal function. The decrease was thought to be halted and even reversed if the obstruction is relieved. However, recent studies showed that the renal damage continues even after release of obstruction. The present study aimed to evaluate the renoprotective effects of multiple therapeutic agents on improvement of renal function and / or prevention of renal damage based on the previous knowledge developed by many researchers on the pathophysiology of acute unilateral ureteric obstruction. Results proved that main pathological change occurs in the obstructive pathology is preglomerular vasoconstriction. Thus, vasodilator drugs improved renal functions. Angiotensin II plays a major role in the pathogenesis of obstructive nephropathy. Thus, interference with A II pathway [through Angiotensin Converting Enzyme Inhibitors (ACEIs) and Angiotensin Receptor Blockers (ARBs)] showed the best renoprotective effect. Also, decreased NO production and endogenous antioxidant may also plays a role especially in renal tissue damage. Thus, ingestion of L-arginine and intake of antioxidant mixture improved (to some extent) renal functions and prevented renal damage. In this study, ARBs and ACEIs were the best regarding renal protection.