الفهرس 
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Abstract
Respiratory troubles continue to be a major problem for the horse industry and constitute a source of economic loss.
Excess production of reactive oxygen species (ROS) is involved in the pathogenesis of airway disorders.
When airway cells and tissues are exposed to oxidative stress or decreased level of antioxidants, the enhanced production of ROS can negatively affect several chronic airway diseases.
Horses suffering respiratory tract disorders have a decreased pulmonary antioxidant capacity, which may render them more susceptible to oxidative challenge.
To evaluate the oxidative stress produced during respiratory tract disorders, venous blood samples were obtained from 64 native breed equines exhibited clinical signs of respiratory tract disorders in three occasions; before, 4 weeks and 8 weeks, respectively following treatment, in addition, 27 native breed equines were randomly selected and considered as a control group.
Twenty (acute and chronic) of these equines were treated with traditional treatment, whereas, other Twenty (acute and chronic) of these equines were treated with traditional treatment in addition, antioxidants combinations; such as Vitamin E, Vitamin C, Vitamin A and selenium. Total antioxidant capacity (TAC), reduced glutathione (GSH), uric acid, superoxide dismutase (SOD), vitamin C (Vit C), malondialdehyde (MDA), nitric oxide (NO), urea, low density lipoprotein (LDL), catalase (CAT) and cholesterol as oxidative stress indicator were measured in the plasma of these equines. In diseased equines there was significant increase in the levels of Total antioxidant capacity (TAC), uric acid, superoxide dismutase (SOD), malondialdehyde (MDA), urea, low density lipoprotein (LDL) and cholesterol, however, there was significant decrease in the levels of superoxide dismutase (SOD), vitamin C (Vit C) and catalase (CAT), while, reduced glutathione (GSH) and Nitric oxide (NO) showed non significant changes when compared with control group. Regarding of post treatment results, Total antioxidant capacity (TAC), reduced glutathione (GSH), vitamin C (Vit C), catalase (CAT) were significantly increased, whereas, uric acid, superoxide dismutase (SOD), malondialdehyde (MDA), urea, low density lipoprotein (LDL) and cholesterol were significantly decreased in group treated with traditional treatment and antioxidants when compared with other group treated with traditional treatment so antioxidants are suggested to be a therapeutic aid for respiratory troubles in equines.