الفهرس 
Introduction
Renal function testOnly 14 pages are availabe for public view
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Abstract
It is well known that fetal & neonatal asphyxia are the main causes of transient renal impairment in newborns. ARF is a possible event, specially in oligo-anuric infants. Early recognition of renal injury is important for maintenance of fluid and electrolyte homeostasis. GFR provides the best overall estimate of renal function and serum creatinine is the most widely used indirect measure of GFR due to low cost and convenience. However, serum creatinine is of limited value in early detection of mild & moderate degrees of renal insufficiency especially in children. Serum cystatin C is a promising indicator of GFR, it is age and gender independent. Cystatin C correlates more or at least as strongly as creatinine in GFR detection. Urinary B2-MG is a sensitive indicator of proximal renal tubular affection. This study was done to assess the changes in renal function (glomerular & tubular) in newborns with perinatal asphyxia using serum creatinine, cystatin C and urinary B2-MG as markers for these changes. Also, to evaluate the sensitivity of cystatin C in comparison to serum creatinine for early detection of mild reduction in GFR. This study was conducted on 35 full term neonates with neonatal asphyxia recruited consecutively from the Nursery of Mansoura University Children Hospital during the period from September 2005 to June 2006. - Cystatin C is a more sensitive marker than creatinine for GFR assessment can be used to predict early improvements in GFR and thus may be used as a prognostic marker of renal function in these patients.