الفهرس 
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Abstract
Acute Myeloid Leukemia (AML) characterized by accumulation of immature precursors and suppression of growth and maturation of normal hematopoiesis. Angiogenesis plays an important role in the growth, progression and metastasis of a solid tumors, as well as haematological malignancies. Acute Myeloid Leukemia (AML) is associated with an increased bone marrow angiogenesis. Angiogenesis induced by angiogenic factors that degrade components of the extracellular-matrix, among these, the matrix metalloproteinases (MMPs) Normal physiological roles for MMPs include bone elongation, angiogenesis, ovulation, sperm maturation, uterine involution, menstruation, enamel formation, antigen processing and presentation, hair follicle development, mammary gland development, and embryo implantation. Matrix metalloproteinases (MMPs) participate in much of the turn over and degradation of extracellular matrix (ECM) components and basement membranes. The catalytic activity of MMPs is regulated at three levels regulation of transcription, activation of latent zymogens, and inhibition by tissue inhibitors of metalloproteinases. Alteration of all three levels of control have been associated with tumor cell progression.