الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Through this investigation, we separate and identificate twenty two natural products from mary’s thistle, Silybum marianum (L.) Gaernt, which is a member of the Asteraceae family, whose fruits have been used medicinally for treatment of several diseases. This study also involves a new trial to improve the dissolution and oral bioavailability of silymarin via its nanoencapsulation in PLGA NPs. These silymarin-loaded PLGA NPs were prepared using “single emulsion-solvent evaporation technique” through a modified procedure. The silymarin-loaded PLGA NPs were then encapsulated in sodium alginate-based pH-sensitive (smart) semi-IPN hydrogel microparticles produced via ionotropic crosslinking in mild aqueous medium. The resulting semi-IPN hydrogel microparticles encapsulating silymarin-loaded PLGA NPs were characterized and evaluated as novel biodegradable carriers that can confer sustained oral release of silymarin in addition to enhancing its overall dissolution and oral bioavailability.