الفهرس 
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Abstract
This study was carried out to evaluate the effect of a soft bone haemostatic agent comprised of water soluble alkylene oxide copolymers in comparison with bone wax on bone healing. Normal adult 45 rabbits Weight 1 kg each were used in this study. They were classified into three equal groups. A bony cavity of the same size (involving the cortex and spongiosa) was done under efficient coolant using normal saline in anterior mandibular area. The induced bone defect in group I was remained without application of local hemostatic material. Alkylene oxide copolymer hemostate (ostene) was applied to defect in second group and bone wax was applied to defects in third group. After 1, 2, 3, 6, and 12 weeks post surgically , rabbits were sacrificed and the mandible excised. The specimens were immediately fixed in 10%formaline solution and processed to be stained with Hematoxylin &Eosin stain.and Trichrome stain. In second group , histological analysis revealed that, no evidence of alkylene oxide copolymer was observed at the application site, no inflammatory reaction occurred at the sites of applications without interfering bone healing. Bone trabeculae formed faster in the 1, 2, 3, weeks in second group than the first group, and became with same rate after 6, and 12 weeks. In thethird group, bone wax-filled defects remained unchanged at all time intervals. Foreign body reaction caused bone destruction of surrounding bone. Water soluble alkylene copolymer is biodegradable material that does not interfere with bone healing in contrast with bone wax which cause foreign body reaction, leading to interference of bone healing.