الفهرس 
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Abstract
Diabetes mellitus is frequently associated with heart disease, that represents one of the most prevalent causes of death worldwide. Several risk factors, including hyperglycemia, insulin lack, insulin resistance and lipid abnormalities seemed to play a major role in the etiology of this disease. The present study was undertaken to evaluate weather prolonged intake of diet rich in plant fibers could play a positive role in reducing development of cardiac disease associated with diabetes. The selected approach was to use two types of plant products, oat bran (as a source of soluble fiber) and wheat bran (as a source of insoluble fiber) to compare their effects in this context. This study was achieved using 36 male albino rats (130-150g) randomly divided into 6 groups as follows: A) Control group (n=6): received balanced diet without any treatment and considered as control group. B) Diabetic rats group: The rats were interperitoneal injected with a single dose of streptozotocin (50 mg /kg body weight). C) Wheat bran rats group: Rats were supplied with a daily dose of wheat bran experimental diet (7% in diet ) for 3 monthes. D) Oat bran rats groups: Rats were received a daily dose of oat bran experimental diet (7% in diet) for 3 monthes. E) Diabetic + wheat bran treated rats group: Diabetic rats were received wheat bran-supplemented diet (7% in diet) daily for 3 months. The present results are summarized as follows: First: when normal rats were fed on diet supplemented with (7% oat or wheat bran) daily for 3 months: the results illustrated that dietary fibers were nontoxic, regarding their effect on the different tested parameters. Second: in the streptozotecin ( STZ) -treated rats (50mg / kg of body weight) several alterations were recorded, including: 1- Significant increases in serum glucose, but significant decreases in serum insulin and glycogen in (liver & heart). 2- Significant increases in lipid profile in serum and both liver and heart, but significant decreases in total protein in serum, liver and heart tissues. 3- Significant increases in malondialdehyde (MDA) and protein carbonyl (PC) levels, whereas the levels of serum Hcy and GSH in both liver and heart were significantly diminished. Third: feeding diabetic rats on diets supplemented with (7% oat or wheat bran) was found to be effective in the management of the above all diabetes-induced changes, with the greatest effect being achieved with oat bran administration. Thus, it can be concluded that diet high in plant fibers, particularly oat bran is useful in reducing the development of heart disease associated with diabetes.