الفهرس 
Introduction and aim of the work Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
The present study aimed to examine the effect of omega-3 fatty acids (EPA / DHA 30% and wheat germ oil as a vehicle) with two different doses (low and high) on some physiological neurological perturbations accompanied with experimental dementia of Alzheimer like type condition induced by aluminum (Al) intoxication in male rats as presented by disturbance in the antioxidant system and neurotransmitter content as well as histopathological changes in the cortex and hippocampus brain regions associated with Al induced oxidative stress in the brain. In the present study, adult male Albino rats, weighing about 130 ± 10 g were used as experimental animals. Rats were divided into 8 groups consisting of 8 animals each. The animals were weighed on a weekly basis and the doses of AlCl3 , omega-3 fatty acids and wheat germ oil vehicle were adjusted according to the body weight. Treatment were continued for 90 days in all groups as follows: 1- Normal control group (no treatment). 2- Wheat germ oil ( given orally by stomach tube comparable to wheat germ oil in omega-3 doses ) 3- Omega -3 fatty acids low dose (given orally by stomach tube as 0.4g/kg b.w.) (Songur et al., 2004) 4- Omega -3 fatty acids low dose (given orally by stomach tube as 0.8g/kg b.w.) 5- Al group (mixed with diet as 100mg AlCl3/ kg b.w.) (Bilkei, 1993). 6- Al and wheat germ oil group (given as in groups 5&2 respectively). 7- Al and omega-3 low dose extract group (given as in groups 5&3 respectively). 8- Al and omega-3 high dose group (given as in groups 5&4 respectively). The overall beneficial effects of omega-3 against aluminum disturbances may be attributed, mainly, to their high ability to scavenge ROS and augment the repair of the antioxidant system, neurotransmitters, and pathological defects. Thus it has been suggested that omega-3 has shown promise in the protection effect of many neurodegenerative diseases including Alzheimer’s disease. Further, warrants the need for molecular studies to elucidate the mechanisms underlying the protective effects of omega-3 component (DHA and EPA).