الفهرس 
Introduction and aim of the essay
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Abstract
The pathophysiology of AML is a multi-step process, arising from genetic alterations in the proto-oncogenes and tumor suppressor genes as well as hematopoietic growth factors and their receptors. All of these lead to continued inappropriate growth, uncontrolled cell proliferation and blocking normal differentiation or preventing apoptosis. According to morphology and cytochemistry, French-American-British (FAB) classification group divided AML into 8 subtypes designated M0 through M7 according to their predominant cell type and the maturation sequence, requiring a blast count of 30% or more for the diagnosis of AML. While, World Health Organization (WHO) classification incorporated cytogenetic and molecular findings in addition to morphological, cytochemical and immunophenotypic features to the diagnosis of AML in which the percentage of blasts required for the diagnosis has been reduced from 30% to 20%. AML has a wide range of clinical manifestations ranging from brief viral like illness up to life threatening sepsis or hemorrhage. The diagnosis of AML requires adequate information that is complementary and have to be integtrated to provide clinicians as much important as the laboratory results that help in monitoring patients progress.