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Abstract Part 1: Studies on the Chemistry of 4-Chloro, 4-Thiothianatoacetylantipyrine, 4-Azido and 4-Nitrosoantipyrine This thesis includes synthesis of 4-substituted antipyrine These 4-substituted antipyrine derivatives were used as starting material. Although dry pyridine seems to be a suitable solvent to induce nucleophilic alkylation reaction of chloroacetylantipyrine with cyclic amidines , only one and the same product with m.p. 235 -237 0C was obtained each time after refluxing the mixture for only 5 minutes. Also, the same product ( mixed m. p.’s and IR spectra ) obtained in better yield (88% ) on heating in the absence of cyclic amidins . Reaction of 4-chloroacetylantipyrine with potassium thiocyante in dry acetone gave the is easily demonstrated from spectral data, and reacted with sodium azide to give the corresponding 4-(azidomethylcarbonyl). Also, reacted with cinammonitrile in ethanol to give compound. also reacted with dimethylformamidedimethylacetal (DMFDMA).Also, 4-nitosoantipyrine reacted with arylidenenitriles Part 2: Chemical and Spectroscopic Studies on N-acetyl-2-cyanoacetohydrazide Derivative In this part, N-acetyl-2-cyanoacetohydrazide, prepared by reacting cyanoacetichydrazide with acetic anhydride, used as starting material for synthesis of 1,2,5-triazepine derivatives. Thus, N-acetyl-2-cyanoacetohydrazide coupled with aryldiazonium salts in ethanol containing sodium acetate. Treatment with chloroacetyl chloride in triethylamine Also, studied by azo-hydrazo tautomerism and the UV-vis absorption spectra using a variety of solvents in concentrations 10-6-10-8 M may be applied to polyester and/or polyamide fibers as disperse dyes |