الفهرس 
Introduction
Experimental and methodsOnly 14 pages are availabe for public view
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Abstract
In the present study, the natural polysaccharide polymer chitin was extracted and purified from the shrimp shell wastes and then modified by N-heterogeneous deacetylation under solid-liquid-liquid phase transfer catalytic condition (SLL-PTC) to produce the biomedicaly and environmentally important chitosan polymer. Further chemical modifications of the resulted chitosan were carried out through graft copolymerization of ethylacrylate (EA) and acrylonitrile (AN) monomers in order to evaluate the potential of the grafted copolymers as a polymeric support for horseradish peroxidase (HRP) enzyme immobilization and carriers in drug delivery systems using methyl orange (MO) as a drug model respectively. On the other hand, chitosan was also modified through the incorporation of the photosensitive α-cyano-4-hydroxycinnamic acid (ACHCA) moiety, which in turn, improves the photo-chemical properties of the resulted chitosan-ACHCA by photo-crosslinking under UV irradiation when casted in form of membranes. Also, the potential of the photo-crosslinkable chitosan-ACHCA hydrogel membranes was evaluated in the formulation of lipase from Candida rugosa immobilization. Another important modification of the prepared chitosan was performed through the incorporation of isatin, then the resulted chitosan-isatin Schiff’s base was crosslinked by glyoxal crosslinker in the presence of magnetite in order to finally produce crosslinked chitosan-isatin magnetic resin (CSIS). The adsorption properties of the crosslinked magnetic CSIS toward Cu2+, Co2+ and Ni2+ were then evaluated. Also, L-aspartic acid enantioselective chitosan/glyoxal molecularly imprinted resin (LAIC) was prepared for selective adsorption and chiral resolution of L-aspartic acid.