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Abstract The study was carried out on 50 allergic asthmatic children in rural district in sherbin,dakahlia and received their medication and immunotherapy from clinical immunology unit,zagazig university hospital.fifty patients were divided into 40 patients as active immunotherapy group and 10 patients as control group. Immunotherapy was administered according to preseasonal schedule six month before pollen season.all patients have positive skin prick test and were evaluated clinically and immunologically pre and post immunotherapy (for six month), Conclusions were reached • Significant improvement in symptom and medication scores were observed after SIT in all patients. • Significant decrease in serum IgE level after SIT in all patients. • Significant increase in serum IgG level after SIT in all patients. So, SIT is considered as a line of treatment for allergic patients with daily pharmacotherapy. |