الفهرس 
Water and electrolyte compositionOnly 14 pages are availabe for public view
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Abstract
Crude tetrodotoxin was extracted from the skin of a Red Sea fish known as Arothron hispidus (Linn.) which belongs to the family Tetraodontidae of the order Plectognathi. The toxin was intraperitoneally administered to experimental animals at three increasing doses of 100, 130 and 160 mg/kg. The effect of this treatment was fallowed up by studying the changes occurring i n the levels of water and electrolytes aa well as i n ATP-aae enzymes known to control the transport system. The study was carried out on different organs of the body of albino r a t s , Rattus norvegicus. The results obtained showed the following : A. WATER AND ELECTROLYTE COMPOSITION : Measurements of the water content of different organs a’t’f all dose levels studied indicated very much limited changes, but regarding the changes i n sodium and potassium contents, only limited increases i n both electrolytes were recorded nearly i n most important organs. Chlorides, similarly, showed moderately limited changes. Comparison of the effects of the toxin on different organs studied showed the following : 1. B-rain: a) Water content : Mon-significant decreases of 0,7574, 0.75% and 1.21% a t dose levela of 100, 130 and 160 mg/kg, respectively were observed. b) Sodium content : Significantly limited increases of 8.09%, 16.3% and 14.08% were observed at dose levels of 100, 130 and 160 mg/kg reapectively. c) Potassium content: lion-significant increase of 3.71%, and significantly limited increases of 13.55% and 12.04 were observed a t dose levels of 100, 130 and 160 mg/kg respectively. d) Sodium potassium ratio: The ~a+/K+was found to change from 2.45 to 2.55, 2.51 and 2.49 at dose levels of 100, 130 and 160 mg/kg respectively. e) Chlorides: Non-significant changes a t dose levels of 100 and 130 mg/kg and significant increase of 11.80% at dose level of 160 mg/kg were observed. 2. Lives: a) Water content: Significant and limited increaaes of 1.92%, 2.16% and 7.46% were observed a t dose levels of 100, 130 and 160 &kg respectively. b) Sodium content : Non-significant increase of 6.56% and significant increases of 13.52% and 40.69% were observed at dose levels of 100, 130 and 160 mg/kg, respectively. c ) Potassium content: Non-significant increases of 7.82% 11.83% and 7.35% were observed a t dose levels of 100, 130 and 160 mg/kg respectively. d) Sodium potassium ratio: The N~+/K+ was found to change from 2.12 t o 2.10 , 2.15 and 2.78 a t dose levels of 130, 130 and 160 mg/kg respectively. e) Chlorides: Non-significant increase of 2.61% a t dose level of 100 mg/kg and significant increases of 17.30% and 60.6P2 and dose levels of 130 and 160 mg/kg respectively, were observed. 3 . Kidney: a) Water content: The water content ahowed non-significant fncreases a t a l l dose levels. b) Sodium content : The ~a+- oont ent showed non-significant changes at dose levels of 100 and 130 mg/kg and significantly limited increase of 17.16% at dose of 160 w/kg Potassium content: Non-significant change at dose level of 100 mg/kg and moderately significant increaaes of 11.63% and 12.53% at dose levels of 130 and 160 mg/kg respectively were observed. Sodium potassium ratio: The N~+/K+ waa found to change from 3.53 to 3.51, 3.43 and 3.68 at dose levels of 100, 130 and 160 %/kg respectively. Chlorides: Non-significant changes were observed at all dose levels. Water content: Non-significant changes were observed at all dose levels. Sodium content: Non-significant increases of 0.28%, 7.55% and 2.12% were observed at dose levels of 100, 130 and 160 mg/kg respectively. Pota~sium content: Non-significant increases of 3.14%, 3.31% and 6.12% at dose levels of 100, 130 and 160 mg/kg. respectively were observed. d) Sodium potassium ratio: The N~+/K+ was found to change from 2.99 to 2.91 , 3.11 and 2.88 a t dose levels of 100, 130 and 160 mg/kg respectively. e) Chlorides: Non-significant changes were observed at a l l dose levels.