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Abstract pollution by pesticides has become one of the oblems especially in Egypt as pesticides are used extensively 1 cotton pests. research was conducted to study the hepatic disorders rkers exposed to cotton dust expected to contain pesticide during the ginning process. For this purpose, all workers (100 & 50 controls) of a cotton gin nery factory (Arabic Company)n El-kom, Menoufiya governorate were investigated. The ‘s gunnery is seasonal and of two 8 hours shifts. This study for two consecutive working seasons (October, 1991 - & (October 1992 - March 1993). s of study were interviewed using specially designed laire including data on medical histories, clinical examination emphasis on liver and spleen. samples were drawn thrice before & after (1991-1992) and r .2-1993) ginnery seasons for serum cholinestrase activity liver function parameters (SGPT, SGOT, SAP, ‘Y-GT direct bilirubin and serum albumin and total serum protein), of hepatitis markers (B & C), haemagglutination test for |