الفهرس 
REVIEW OF LITERATUREOnly 14 pages are availabe for public view
 |  | from | 194 |  |  |
| | | from | 194 | | |
Abstract
Asthma and chronic obstructive pulmonary disease are chronic diseases of the bronchi, characterized by airflow limitation and inflammation. Whereas in asthma airflow obstruction is reversible and variable, in COPD it is fixed and carries a worse overall prognosis.
Cigarette smoking is the major risk factor associated with the development of chronic obstructive pulmonary disease but genetic factors are though to make some individuals more susceptible to pulmonary effects of tobacco smoke than others.
Mucosal inflammation is an integral component of the asthmatic and obstructive pulmonary disease airways and is considered to be central in the pathogenesis of airway dysfunction.
In the inflammatory response of the lung, circulating inflammatory cells accumulate in the pulmonary capillaries and migrate through the vascular endothelium to the submucosa of the airway via cytokine induced expression of cell adhesion molecules where these cells contribute to the :;iation and perpetuation of the changes in airway structure and function.
This study was carried out to evaluate the role of the intercellular dhesion molecule-i (ICAM-1) and interleukin-8 (IL-8) in the pathogenesis f chronic obstructive pulmonary disease and bronchial asthma.
The present study was conducted on 80 subjects: 60 patients and 20 controls. The patients were attendants of outpatient clinic of Chest )epartment, Menoufiya University Hospital. They were classified into 3Group I: Included 30 patients with bronchial asthma. This group vas subdivided into 2 subgroups: Ia: atopic asthma and Ib: non atopic Group II: Included 30 patients with COPD.