الفهرس 
Physicochemical propertiesOnly 14 pages are availabe for public view
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Abstract
Propofol is an intravenous anaesthetic agent which has a short half- life and minimal accumulation. The kinetics of propofol allow for rapid induction of anaesthesia, adequate maintenance, and rapid recovery of consciousness. Sevoflurane, a new inhaled anaesthetic, is almost ideal for inhalation induction of anaesthesia. It provides rapid and smooth induction. Its rapid elimination accounts for the rapid recovery of consciousness. However, both anaesthetics have been reported to cause transient sub-clinical liver dysfunction in non-hepatic patients.
Because of the liver’s remarkable functional reserve, clinical manifestations are often absent until extensive hepatic damage has already occurred. In patients with compensated or occult liver disease, minor stress may precipitate overt hepatic dysfunction. The adverse effects of anaesthesia and surgery can precipitate hepatic dysfunction in these patients
We compared propofol to sevoflurane anaesthesia in 30 hepatic patients undergoing non-hepatic surgery in regards to induction and recovery criteria, haemodynamics and effect on liver function tests.
We found propofol to be associated with a faster induction but slower recovery than sevoflurane. Propofol induction was associated with 20% incidence of pain on injection, whereas, sevoflurane was associated with 33% incidence of breath holding. Recovery from sevoflurane anaesthesia was associated with 20% incidence of excitement and PONy.