الفهرس 
Aim of The WorkOnly 14 pages are availabe for public view
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Abstract
Hepatosplenic schistosomaisis is the most prevalent form of hepatic fibrosis world-wide The pathogenesis of schistosomal hepatic fibrosis is controversial, but in a recent study done by Dunn et al (1977) it was found that hepatic fibrosis is marked by excessive deposition of newly synthesized liver collagen. Moreover, the rate of collagen synthesis in hepatic schistosomiasis has been proved to be higher than in normal livers (it was 4-25 fold higher than normal) and this increased rate of synthesis was correlated with the increased free proline pool in the fibrotic livers.
Collagen, the most conspicuous component of the fibrotic process is an extracellular secretion from sepcial fibroblasts and it is protein in nature. The principal amino acids composing collagen are glycine (33.5%), proline (12%) arid hydroxyproline (10%).
Collagen is the only protein containing hydroxyproliiie in fixed appreciable amount (10%), so it is used as indicator for measuring collagen content in a tissue.