الفهرس 
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Abstract
In Egypt, ovarian tumors constitute about 13.33% of the female genital tract malignancies fMohh/ffr JM! mme USA, it constitutes about 4% of all cancers in women, ranking the fifth most common malignancy; it is also the fifth leading cause of death in females. Despite attempts at early detection 60% of patients have extrapelvic spread of the disease at the time of diagnosis. The lifetime risk of developing ovarian cancer is 1.5% or(1/70) and one woman in 100 will die of the disease (Brewer etaL, 2003).
Surface epithelial tumors, numerically the most important group of neoplasms, are thought to derive from the epithelium that normally lines the outer aspect of the ovary (Sculty et al., 1998). Surface epithelial tumors are classified according to cell types to serous, mucinous, endometrioid, etc and according to atypia and invasiveness to benign, borderline, and malignant(Rosai, 2004).
COX-2 is inducible enzyme. It is involved in cell response to growth factors, tumor promoters, and cytokines that induce its expression (Denkert et al., 2002). COX-2 is frequently expressed in human adenocarcinomas especially ovarian adenocarcinoma. Few studies were done on COX-2 expression; they suggest that elevated expression of COX-2 is associated with poor survival in ovarian carcinoma patients (Erkinheimo et at, 2004).
The aim of this work is to evaluate COX-2 expression in ovarian;arcinoma cases and its correlation with well-known clinicopathologic irognostic parameters.
The material of this study consisted of archival paraffin blocks of 41 ases of malignant epithelial ovarian tumor cases (23 serous, 9 mucinous, 6 idometrioid, 1 Brenner, 1 clear cell carcinoma and 1 undifferentiated rcinoma); 6 borderline cases (3 serous and 3 mucinous) and 9 benign.