الفهرس 
The cell
MATERIALS AND METHODSOnly 14 pages are availabe for public view
 |  | from | 176 |  |  |
| | | from | 176 | | |
Abstract
This work was undertaken with the aim of studying the mutagenic effect of metronidazole (flagyl) alone or conjugated with natural substance such as Nisella sativa both in vivo and in vitro.
IN VIVO STUDIES:
These studies were carried out on 110 swiss albino mice and classified into two main groups:
Group I: studied bone marrow chromosomal aberrations and mitotic index and was subdivided into 5 subgroups:
[Subgroup 1: included 15 mice, served as-ve control, each was injected with 0.5 ml saline I.P. The animals were sacrified after 1, 3 and 7 days (5< animals/period).
Subgroup 2: included 5 mice, served as +ve control, each was injected rith a single dose of mitomycin C 20 micro-gm/mouse/day l.P and aerified after 24 hours.
ibgroup 3: included 10 mice, 5 of them were injected l.P with a single sse of flagyl 160 mg/kg/days (3 mg/mouse/day), while the others were(jected with the same single dose of flagyl conjugated with oral intake.