الفهرس Only 14 pages are availabe for public view
 |  | from | 147 |  |  |
| | | from | 147 | | |
Abstract
Patients with epilepsy may have several hormones with different serum levels than those of similarly aged healthy people. Moreover, patients with epilepsy often complain about symptoms that may be caused by disturbances in their hormonal balance.
Enzyme-inducing AEDs are known to result in decreased thyroid hormones. However, all patients were clinically euthyroid, and these changes were reversible after AED withdrawal.
Carbamazepine therapy has certain effects on thyroid function: it decreases the serum thyroid hormone levels, but allows the serum thyrotropin concentration and TSH responses to thyrotropin-releasing hormone to remain normal. It has been speculated that these low serum thyroid hormone levels are due to the induction of the hepatic P450 enzyme system by carbamazepine.
Epileptic seizures have a transient effect on serum pituitary hormone and cortisol levels. A moderate increase in serum prolactin, due to anticonvulsant medication, has been reported.
Aim of the work:
To study the effect of AEDs on the functions of the endocrine system in epileptic patients.
Levels of pituitary hormones as Prolactin and TSH, as well as Growth hormone will be evaluated in epileptic patients receiving AEDs compared to healthy age-matched control group.
This allows insights into the endocrine system so that we could evaluate the extent to which epilepsy & long term AEDs influence the endocrine functions of such patients.