الفهرس Only 14 pages are availabe for public view
 |  | from | 145 |  |  |
| | | from | 145 | | |
Abstract
Chronic Myeloid leukemia is aclonal hematologic malignant disease arising in the stem cell compartment. The hallmark of CML is the BCR/ABL fusion gene which result from reciprocal translocation which is formed as result of the (9,22) translocation , asubstantail minority of CML patients has large deletions adjacent to the translocation break point on the derivative 9 chromosome which provide diagnostic and prognostic significance with direct impact on patient management.
The aim of this study is to detect the 9q 34 deletion prevalence in CML patients besides the detection of the BCR/ABL fusion gene and its prognostic value
The present work included:
43 patients in different phases of CML 10 healthy individuals of comparable age and sex acting as control group.
The patients were subjected to:
Detailed history and thorough clinical examination.
A laboratory investigation includes.
Complete blood picture
Bone marrow aspiration
LAP –score
Philadelphia chromosome detection by FISH.
9q34 deletion detection by FISH.
After being fully investigated,CML patients received treatment and were observed for periods from 6 to 30 months.