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Abstract
Type 2 diabetes mellitus (DM) is associated with an increased risk of peripheral vascular disease (PVD), but within the diabetic population the relationship between various risk factors of atherosclerosis and PVD has not been clearly defined. Conventional and genetic risk factors have been reported to play a role in the pathogenesis of vascular disease, but do not explain the lower burden of cardiac and PVD. So, the relationship of lower extremity arterial disease to the different risk factors for atherosclerosis in type 2 diabetes mellitus is a matter of continuing investigation. The inflammatory marker C-reactive protein (CRP) predicts risk of myocardial infarction and thromboembolic stroke, whether increased levels of CRP are associated with the development of symptomatic PVD is unknown.
We studied 60 cases all were subjected to clinical examination and laboratory work-up in the form of C-reactive protein and lipid profile (total cholesterol, triglycerides, high density and low density lipoproteins). Statistical analysis was done to demonstrate any relation between diabetic macro-vascular complications and those clinical and laboratory parameters.
CRP was higher in diabetic patients with vascular complications when compared to those without vascular complications. Also the lipid profile is statistically higher in the patients with diabetic macro-vascular complications compared to those without