الفهرس 
POLYCYSTIC OVARIAN SYNDROMEOnly 14 pages are availabe for public view
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Abstract
This study was performed to evaluate the effectiveness of laparoscopic
ovarian drilling alone in inducing ovulation, restoring regular menstrual pattern
and pregnancy rate compared to laparoscopic ovarian drilling plus clomiphene
citrate therapy in women with polycystic ovary syndrome.
50 women with polycystic ovary syndrome were selected for this work
from those attending the infertility clinic at Ain Shams University Hospital.
The diagnosis of polycystic ovary syndrome was based on clinical,
sonographic and endocrinological documentation.
Those who had fulfilled the primary inclusion criteria (n=50) were
scheduled for laparoscopic ovarian drilling and all those women were divided
into two equal groups each involved 25 women. Women of the first group
(n=25) were followed up without any treatment after LOD while those of the
second group (n=25) were treated by clomiphene citrate with starting dose of
50 mg/day for 5 days from day 5 to day 9 of the cycle for 2 cycles if the
ovulation not occurred this dose was increased to100 mg/day for 2 cycles and
to 150 mg/day if ovulation was not occurred for another 2 cycles.
All participants were followed up for the next 6 months to evaluate the
effect of the procedure on the clinical presentation and the occurrence of
ovulation by serial vaginal ultrasound (folliculometry) and pregnancy rate.
Follow up of those women included in this study was done through
repeated transvaginal ultrasound folliculometry which started at day 11 of the
cycle and every other day according to the follicular size. Good response is
achieved when at least one mature follicle reached 18 – 24 mm in diameter
(Speroff et al, 1999). If there was no follicular response till 20th day of the
cycle or if the size of the follicle becomes > 24 mm, this consider bad response
(-ve result) (Yarali et al, 1999).
If delay of menstruation for one week had been occurred, pregnancy test
was performed; positive pregnancy test was considered good response of
therapy.