الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
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Abstract
Hepatorenal syndrome is still one of the most important challenges of medicine in the 21st century.
It is defined as functional renal failure in advanced cirrhosis and ascites. Morphologic abnormalities of the kidneys are frequently absent and tubular function is preserved. Patients with the hepatorenal syndrome are characterized by progressive splanchnic and systemic vasodilatation and decreased effective arterial blood volume. Compensatory activation of vasoconstrictor/ systems maintains systemic hemodynamic stability but causes progressive afferent renal vasoconstriction, leading to reduction of glomerular filtration rate. Renal failure may be rapidly
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progressive (type I hepatorenal syndrome, frequently associated with spontaneous bacterial peritonitis) or may develop more slowly (type II).
One of the major vasoconstrictor factors that regulate renal perfusion is the renin-angiotensin-aldosterone system. It was an important factor to be considered as potential mediators of renal vasoconstriction in HRS.
For these reasons, this study was planned to show the level of plasma
renin activity, plasma All and serum aldosterone in hepatorenal syndrome
patients compared to each of ascitic patients, cirrhotic patients and control
subjects to assess if they have a role in the pathogenesis of HRS.