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Abstract
Bone metabolism abnormalities observed in chronic liver disease are refered to as hepatic osteodystrophy.It is not infrequent in hepatic patients with prevalence rate ranging from 13% to 70% dependending on the population studied and the diagnostic criteria used to define bone disease.
The pathogenesis of hepatic osteodystrophy is unclear and likely is multifactorial.Disturbance in endocrine calcium-PTH-vitamin D axis seem to play arole in pathogenesis of osteometabolic disturbance. The liver is an important organ in hydroxylation of vitamin D into its active metabolites. Vitamin D and PTH regulate bone mineral serum levels s and bone remodeling. Consequently, chronic liver disease may interfere with vitamin D synthesis and bone metabolism.