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Abstract
Diagnosis of congenital or neonatal infection is often based on clinical signs. However, clinical symptoms of infections may not be specific, and for this reason early diagnosis is often determined on results of laboratory tests, which may not currently be adequate (Fjaertoft et al., 1999).
A more reliable method of detection of infection may be the demonstration of activated lymphocytes, which can be conducted rapidly and before the isolation of the infective organism (Hodge et al., 2004).
Hodge et al., 1998 demonstrated that detection of up-regulation of CD25 & CD45 Ro, an activated / memory isoform of CD45 present on T cells, are sensitive and reliable markers of neonatal infection.
El-Sameea et al., 2004 studied the role played by the natural killer cells in neonatal sepsis and evaluate the sensitivity of these cells number as assayed by CD56 positive as diagnose marker in infants with suspected early neonatal sepsis.