الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
SUMMARY AND CONCLUSION
SUMMARY AND CONCLUSION
This study evaluated the effect of clomiphene citrate on
the ovary of adult rat. Eighty selected female rats with regular
estrous cycle checked with vaginal smear once daily were used
in this study. These rats were divided into two groups. The
control group (40 rats) was injected by physiological saline 2ml
subcutaneously for 10 consecutive days. The treated group was
divided into two subgroups. Subgroup (A) was injected by
clomiphene citrate in low dose (0.3mglkg body weight/day)
subcutaneously for 10 consecutive days. Subgroup (B) was
injected by clomiphene citrate in high dose (3.0mglkg body
weight/day) subcutaneously for 10 consecutive days. The rats of
control and treated groups were killed 24 hours after the last
injection. The right ovary of each rat was collected and prepared
for light and electron microscopes.
The diameters of non-atretic and atretic follicles were
measured by ocular micrometer in the serial sections of the
ovary at magnification of 100. The numbers of non atretic and
atretic follicles and corpora lutea were counted. Statistical
analysis were made using the t-test among the studied groups.
The low dose of clomiphene citrate did not affect the number of
non atretic follicles ranging from 51-4001J.min diameter, butit
decreased the non-atretic follicles larger than 400J.l.m In
SUMMARY ANI) CONCLUSION
diameter. It also increased the number of atretic follicles ranging
. ’ . from 30 to 400l!m in diameter. The high dose of clomiphene
citrate increased the number of non atretic follicles ranging from .
30 to 400l!m in diameter, but it decreased the non atretic
follicles larger than 400l!m in diameter. It also increased ’the
number of atretic follicles ranging from 51 to 600l!m in
diameter. Both doses inhibited the ovulation rate through
decreasing the number of mature follicles larger than 400l!m in
diameter, increasing the atresia of follicles and decreasing the
number of ftrst type of corpus luteum.
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