الفهرس 
HELICOBACTER PYLORI AND chrONIC URTICARIAOnly 14 pages are availabe for public view
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Abstract
SUMMARY AND CONCLUSION
Chronic idiopathic urticaria is a subtype of urticaria in which wheals recur on most days for at least six weeks without recognizable specific cause. Since the clinical entity is common, possesses a capricious course and easily recognized, it is frequently associated with concomitant events. Although fungal or bacterial infection, food, medication, metabolic and hormonal abnormalities, malignant conditions and emotional factors have been claimed as causes, proof for their etiologic relationship is usually lacking.
One of the possible causes of chronic urticaria is helicobacter pylori, a microaerophilic gram negative, flagellated spiral shaped bacterium closely associated with gastric mucosa in most patients with duodenal ulcer and 80% of patients with stomach ulcer and is a risk factor for gastric cancer.
To explore the role of helicobacter pylori in chronic urticaria, 30 patients of chronic idiopathic urticaria were selected from the out-patient clinic of dermatology, Benha University Hospital, (22 females and 8 males). Their ages ranged from 16 years to 63 years (the mean age 35.37 + 9.22) the patients reported persistence of disease from six weeks to 18years (the mean duration 5.09 + 0.98).
A primary diagnosis of chronic idiopathic urticaria was made when an etiologic factor accounting for the majority of lesions could not be elucidated on history and physical examination.
Ten volunteers of different age and sex represented the control group of this study.
The two groups accepted to undergo gastroscopic examination and gastric mucosal biopsy. The biopsies were stained by both Haematoxyllin and Eosin & Giemsa stain for detection of helicobacter pylori and degree of gastric inflammation. HP was +ve in 24 patients of chronic urticaria and 6 control out of 10.
Statistical analysis showed significant difference (p value <0.05) between chronic urticaria group and control group regarding the prevalence of helicobacter pylori.
Also it showed significant difference (p value <0.05) between degree of urticaria and the degree of gastric inflammation in patients with chronic urticaria supporting the role of helicobacter pylori infection in chronic urticaria.
So it could be concluded from this study that the prevalence of helicobacter pylori is high in patients with chronic urticaria included in this study that is why we recommended investigation for helicobacter pylori infection in patients with chronic idiopathic urticaria, especially, if they complain of gastric troubles, as treatment may help in recovery of chronic urticaria in these patients.