الفهرس 
Material And MethodsOnly 14 pages are availabe for public view
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Abstract
The study was c~rri8d out on twenty patients with endoscopicaly proven duodenal ulcert aiop”y was talcen from tha: mucosa as close aiS
possible to the ulcl2r in patients with ac t i.va dcode naI
ul ce r but it ia. taken from lIite-CIOBS t o the pre vious
u~cer ~~te 1Q tho~e p~tien~B with hn~led ulce~5~·
Al~ specimenB cbta{n~d w.~.~l~.d in 10’ bu£fu~ed
neutral formalin, fi~d in p~.ffin wax and seotioned
at ~ microns. tach biopsy ’oila-. lItllined with naematoxylin
and eosin, with Alcian blue fa Gxl at pH :’H5
for acidic mucins and periQdic acid schiff (PAS)
for neutral mucins. Patholog-ical study· i ncJ.l.1ded
vi 11,,1.1” m””ph” 1”9Y, pn,v ••l~nca of villi with gastric
epitheliu~, p~eva~ence of villi with 9aR~ric Rpitheliu.
in each se~, prevalence of villi w1~h qastr1c ~pith~lium
in rel~tion to H+ ion concentration (free- acidity).
site of gastric: cpitheliW’ll in re1~t:lon to the villous
whether ~t the tip, side. crypt. or co.e~in9 ~he
whole villous.
The study also in~J.~~e~ histochemical chan~Bs
in muooua,
As i”Egl’I ~dB pathologieal study, the resu Its
showed that t i ve pat.ienta I5howed normal vlLli (25’) ,
raJ)
twe 1ve patients showed atrophic vil1i (~O% l and three
pati~nts showed short blunt villi iI5t). I~ waS found
tl1at the percenta’]e of the ~ff””c!:””d vi IIi was 15.9%
from ~h~ t-ota 1 viJ.li ,!IIRCI• tl,~ prev/IIIence of vi lli
with gastric epithelium in ~emale8 was mo~e than
in males and a~ the free acidity Wft8 below 30 rnEq!lit.
~o 9Aslric epithelium wa~ detected.
It w~~ found also that, as frs8 acidity inCrea5ec
the g~5~ric· epilhcliu~ W~$ detected at the tip of
the villou~~ There was no assooj~tlon between th~
intensity of aellular infiltration and the presence
of gastric cells.
/!.5regards histochel1lical changes. it: ”’as foun(l
that in active duodenal uloer the Al~la~ blue staining
acid mucosubstance in goblet oells were redUCed ’lJlQ
th~ goblet cells E1v~nl di.llp~.red at the lIallle time
periodic acid schLff IPAS J lIbdninq neutral muc:os ubstance5
appeared in ~h~ cr@ll~ ~t the surface epithelium.
J.~ healed duo~enal ul~e~ the chan9Bs ~~re reversed.
In conclu~ton our data help to study the pathogenesis
of ~uodeno!ll ulcer the appearance of gastric
epithel~al cells near the tips af the villi meanB
that they had been formec by altsratian of ad~lt
i~t:est:in.!ll eel \.S or they were formed in the crypts
and migrated 5S do normal cells.