الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
Cryptosporidium is an important enteropathogen and has gained much attention as a major cause of diarrhoea worldwide.
In the present study, 1087 diarrhoeal stool samples from patients of all ages were examined to detect Cryptosporidium oocysts using:
1-Modified Ziehl-Neelsen staining technique (has done for all samples).
2-Direct immunofluorescent technique (has done for 200 samples).
The positive cases (I 50) were subdivided into 3 groups:
■Group I (50 patients) were treated with nitazoxnide:
-The adults were treated with one tablet (500mg.) every 12 hours for 3 successive days.
-the children below 4 years were treated with 5m1(100mg) every 12 hours for 3 successive days.
- the children above 4 years were treated with 10 ml (200mg.) every 12 hours for 3 successive days.
■Group 11 (50 patients) were treated with co-trimoxazole:
-the adults were treated with 2 tablets(sulphamethoxazole 800mg + trimethoprim 70mg), every 12 hours for 6 successive days.
-the children below 4 years were treated with 5m1. (sulphamethoxazole 200mg + trimethoprim 40mg)
-The children above 4 years were treated withl0m1 every 12 hours for 6 successive days.
■Group III (50 patients) have taken placbo.
Re-examination was done at two occasions for all the treated patients to evaluate the clinical as well as the parasitologic response.
1-Cryptosporidium is an important cause of diarrhoea. The prevalence in the 1087 diarrhoea, stool samples studied was 150 positive cases (13.8%)
2-Children below 2 years are the most susceptible hosts (20%).
3-Cryptosporidium infection is slightly more prevalent in females.
4-There is no significant association between Cryptosporidium and other parasites.
5-Abdominal pain is the main presenting symptom among all cryptosporidium infected cases after diarrhoea.
6-Of the examined cases 26.67% gave history of animal contact. This proves the zoonotic nature of cryptosporidiosiis but it also shows that animal contact is not the only possible mode of transmission of Cryptosporidium.
7-Incidence of infection is higher in summer months.
8-Regarding diagnostic methods, the direct immunofluorescent technique proved to be more sensitive and specific than the modified Zeihl-Neelsen staining technique.
9-Regarding treatment, Nitazoxnide was proven to be effective against Cryptosporidium infection producing both clinical and parasitologic response. Also, it was proven to be safe, well tolerated with only minor nearly non-specific side effects. On the other hand, co-trimoxazole was found to be less effective against Cryptosporidium infection.
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