الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
The work was perfor.ed on 5~ patients selected
,from those attending the tropical Imedicine department of
Benha University also equivalent 20 control subjects.
Patients were grouped accordingto their clinical state
\
and pathological picture of the liver as follows:
Grgyp I
COllprised 23 patients with pure
hepatosplenollegaly with or without cOllpensated
liver.
glAu9 II
Comprised 10 patients with acute viral hepatitis
type B.
CJJ9YP III
Comprised 11 patients with pure chronic active
hepatitis.
Qlppp IV
Comprised 10 patients ”with mixed schlstosoll8l
post viral hepatitishepatospleno_galy.
Comprised a 20 norll8l subjects. They were
clinically free and .had negative ·intrader_l test
for schistosomiasis and negative ”BsAg in their
sera.
All studied cases were subjected to the following
studies.
Complete history taking and full clinical
examination.
Urine and stool analysis.
sigmoidoscopic examination with rectal snip
which was examined by transparency technique for
schistosoma ova.
Intradermal test for schistosomiasis.
Liver function tests.
Total serum proteins•
.Serum glutamic oxaloacetic transaminase (SOOT).
Serum glutamic pyruvic transaminase (SGPT)•
.Berum bilirubin.
Reversed passive haemagglutinatlon test for
detection of .HBsAg in serum.
Liver biopsy stained by ordinary haematoxYlin and
Basin stains and special orcein stain which staines
”BsAg in liver cells•
.Ind.irect i_unofluorescence test to detect and
:enu_rate total and subpopulationg’ofT-lymphocytes
usinCjmonoclonal..antibodies.
Results of the Work Can be Summerized as:
1- SYlI\pt:omsand signs of liver cell failure were most
marked in group I and IV.
2- Urine, stools and rectal snips examination reve;t1ed
that active cases of schistosomiasis were more in
group I and group IV.
3- Intradermal test for schistosomiasis was posit ive
.in patients of group I and IV.
4- Liver Function Test.
a- Total serum proteins showed significant
decrease. in group I and IV.
b- Serum glutamic oxaloacetic transaminase (SnOT)
was increased in group I and III.
c- Serum bilirubin was incr’eased specially in
group II and group IV which was highly significant
and increased in group III also.
”
As regards results of HHsAg in the serum. All cases
of group I were negative HBsAg in their sera. Some cases
of group III and group IV were positive, all cases of
group II were positive.
As regards pathologically examination of liver
biopsies, in ,group I chosen with pure schistosomal
l~fection hepatic architecture was preserved, but lohular
patter was destorted in variable degrees due to the
increased amount of fibrosis in the thickned portal
tracts. It was formed of histocytes, lymphocytes, plasma
cells and’ some eosinophils. Liver pathology with
negative orcein stain.
The diagnosis of schistosomal hepatic affection was
based on the detection of schistosomaI ova and the
presence of blackish schistosomal pigments inside
kupffer cells.
In group III cases chosen with chronic active
hepatitis or chronic persistant hepatitis liver biopsy
showed picture of chronic active hepatitis presented by
reaction in thickned portal tracts was formed of fibrous
tissues. Irregular septae of fine fibrous tissue infiltrated
by lymphocytes extend in between lJ.ver cells.
Piecemeal mecrosis of some liver cells adjacent to the
fibrous septae was seen in some cases. Orce:Lnstain was
positive.
In group IV liver pathology showed
active hepatitis and schistosomiasis
Orcein stain.
milced chronic
with positive
In group II no liver biopsies were done in the
acute stage.