الفهرس 
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Abstract
Evidence supporting the role of enamel matrix proteins in periodontal regeneration is increasing. There is evidence supporting the role of this natural substance in the regeneration of cementum, periodontal ligament and alveolar bone. The actual mechanism of action and proper sequence of the cascade of its multiple actions are still not accurately identified. In vitro, animal and human studies are still required to further understand its role in periodontal regeneration.
Bovine anorganic protein has been studied in human intrabony defects clinically and histologically and is recommended to be used in combination with other materials. The mixture of this graft with enamel matrix derivative is not novel today but is still under investigation. The present study was conducted to evaluate clinical and radiographic changes after treatment of three osseous wall defects using a combination of bovine-derived xenograft (Bio-Oss®) and enamel matrix derivative (Emdogain®) compared to bovine-derived xenograft (Bio-Oss®) alone. Twenty intrabony defects in ten nonsmoking female patients with ages ranging from 35-45 years were selected from the outpatient clinic, department of Oral Medicine and Periodontology, Faculty of Oral and Dental Medicine, Cairo University Clinical parameters including pocket depth and attachment level were recorded before the surgical procedure. On the other hand, radiographic linear (CEJ to base of the defect and CEJ to the alveolar