الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
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S~ARY ~~D CONCLUSIONS
It was aimed in this study to find a relation
between thyroid gland dysfunction and mammary carcinoma
in comparison to benign breast lesions and
a matched healthy control groups.
Thorough history was undertaken for all cases
with stress on previous thyroid operations or medications,
irradiation to neck region, menstrual history
and family history of similar disorder.
Clinical examination was carried out wi th stress
on breast examination, neck examination for any thyroid
enlargement, supraclacicular swellings and scar
of previous operations. Serum levels of TSH, T3 and
T4 were estimated for all cases using a radioimmunoassay
procedure.
The incidence of goitre in breast cancer groups
was relatively high (35% & 45%). Breast cancer occurs
in earlier age in goitreous than in non goitreous cases.
Clinical hypothyroidism was found among patients
wi th early and advanced breast cancer in a percentages
of 35% and 15% respectively.
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A relative young age group in breast cancer with
clinical hypothyroidism in comparison to euothyroid
subjects was detected.
There was significant increase in serum TSHlevel
and significant decrease in serum TJ level in cancer
breast groups. Theses changes were more prominent in
cases with goitre and clinical hypothyroidism. The
possible explanation was offered.
The mean age of patients with cancer breast was
significantly lower in patients having previous thyroidectomy.
There was significant increase in serum
level of TsH and significant decrease in serum level
of TJ in cases with previous thyroidectomy as compared
to CaSEl6 wi thout previous thyroidec tomy, The explanation
was given.
Among20 Cases examined in the advanced breast
Cancer group 12 were cachectic. The impairment of
thyroid function was more evident in cachectic than
in non cachectic cases. The possible explanation
was offered.
Fourteen out of 20 cases in advanced breast cancer
group were irradiated and the thyroid function
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impairment was more prominent in irradiatedthan in nonirradiated
cases. The possible cause was explained.
Obesity was relatively common (65% & 45%) in early
and benign groups respectively.
In the early breast cancer group there was significant
rise in serum level of TSH and significant
decrease in serlml level of TJ in obese cases as compared
to non obese ones. On the other hand there was
non significant differences in serlml levels of TSH
and TJ in obese cases compared to non obese ones in
benign breast lesions group. The possible explanation
was gi.ven ,
Diabetes kellitus was present in a percentages
of (J5% & 25%) among advanced and early breast cancer
groups respectively. Thyroid function impairment was
more prominent in diabetic than in non diabetic cases
and this was attributed to t~ hyperlipedemia. and hyperestrogenemia
that depress the thyroid function.
As goitre is endemic in Egypt, obesity is relatively
co~~on, and as the latters are risky preventable
factors for cancer breast development one could
suggest further studies to clarify such relationship.