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Abstract 137 S~ARY ~~D CONCLUSIONS It was aimed in this study to find a relation between thyroid gland dysfunction and mammary carcinoma in comparison to benign breast lesions and a matched healthy control groups. Thorough history was undertaken for all cases with stress on previous thyroid operations or medications, irradiation to neck region, menstrual history and family history of similar disorder. Clinical examination was carried out wi th stress on breast examination, neck examination for any thyroid enlargement, supraclacicular swellings and scar of previous operations. Serum levels of TSH, T3 and T4 were estimated for all cases using a radioimmunoassay procedure. The incidence of goitre in breast cancer groups was relatively high (35% & 45%). Breast cancer occurs in earlier age in goitreous than in non goitreous cases. Clinical hypothyroidism was found among patients wi th early and advanced breast cancer in a percentages of 35% and 15% respectively. lJ8 A relative young age group in breast cancer with clinical hypothyroidism in comparison to euothyroid subjects was detected. There was significant increase in serum TSHlevel and significant decrease in serum TJ level in cancer breast groups. Theses changes were more prominent in cases with goitre and clinical hypothyroidism. The possible explanation was offered. The mean age of patients with cancer breast was significantly lower in patients having previous thyroidectomy. There was significant increase in serum level of TsH and significant decrease in serum level of TJ in cases with previous thyroidectomy as compared to CaSEl6 wi thout previous thyroidec tomy, The explanation was given. Among20 Cases examined in the advanced breast Cancer group 12 were cachectic. The impairment of thyroid function was more evident in cachectic than in non cachectic cases. The possible explanation was offered. Fourteen out of 20 cases in advanced breast cancer group were irradiated and the thyroid function lJ9 impairment was more prominent in irradiatedthan in nonirradiated cases. The possible cause was explained. Obesity was relatively common (65% & 45%) in early and benign groups respectively. In the early breast cancer group there was significant rise in serum level of TSH and significant decrease in serlml level of TJ in obese cases as compared to non obese ones. On the other hand there was non significant differences in serlml levels of TSH and TJ in obese cases compared to non obese ones in benign breast lesions group. The possible explanation was gi.ven , Diabetes kellitus was present in a percentages of (J5% & 25%) among advanced and early breast cancer groups respectively. Thyroid function impairment was more prominent in diabetic than in non diabetic cases and this was attributed to t~ hyperlipedemia. and hyperestrogenemia that depress the thyroid function. As goitre is endemic in Egypt, obesity is relatively co~~on, and as the latters are risky preventable factors for cancer breast development one could suggest further studies to clarify such relationship. |