الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
Summary and conclusions
Chronic liver disease has always been considered as a major health problem in Egypt. It
contributes, a considerable morbidity and mortality. Importantly, it has a bad negative effects
on the work performance and the national income.
The overall studies reported that the prevalence of peptic ulcer in patients with liver diseases is
higher than in age matched control populations and that peptic ulcer has been reported with
increased frequency in patients with chronic liver disease.
The death rate from peptic ulcer in cirrhotic patients is five times higher than in the general
population .. Similar results was reported by most researchers.
The most noteworthy finding of the current study was that the ulcer healing rates is lower in the
presence of associated liver diseases than in control population .
The therapeutic gain in ulcer healing with [ranitidine 600 mg/day] at the 4-week period over the
current dose [300 mg/day] , support the postulated mechanisms of healing of peptic ulceration
emphasising suppression of gastric acid secretion.
Neither portal hypertension nor Helicobacter pylori was proved to be a factor in the pathogenesis
of peptic ulcer in cirrhotic patients .
The possible factors which may have a role in peptic ulcer etiology in cirrhotic patients is PGE2
defficiency ,decreased mucosal oxygen tension and blood flow, it is recommended that these
factors need further studies.
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