الفهرس | Only 14 pages are availabe for public view |
Abstract Summary and conclusions Chronic liver disease has always been considered as a major health problem in Egypt. It contributes, a considerable morbidity and mortality. Importantly, it has a bad negative effects on the work performance and the national income. The overall studies reported that the prevalence of peptic ulcer in patients with liver diseases is higher than in age matched control populations and that peptic ulcer has been reported with increased frequency in patients with chronic liver disease. The death rate from peptic ulcer in cirrhotic patients is five times higher than in the general population .. Similar results was reported by most researchers. The most noteworthy finding of the current study was that the ulcer healing rates is lower in the presence of associated liver diseases than in control population . The therapeutic gain in ulcer healing with [ranitidine 600 mg/day] at the 4-week period over the current dose [300 mg/day] , support the postulated mechanisms of healing of peptic ulceration emphasising suppression of gastric acid secretion. Neither portal hypertension nor Helicobacter pylori was proved to be a factor in the pathogenesis of peptic ulcer in cirrhotic patients . The possible factors which may have a role in peptic ulcer etiology in cirrhotic patients is PGE2 defficiency ,decreased mucosal oxygen tension and blood flow, it is recommended that these factors need further studies. Page70 . ~ _.. -_.-.~-._- |