الفهرس 
The plateletsOnly 14 pages are availabe for public view
 |  | from | 129 |  |  |
| | | from | 129 | | |
Abstract
To study the role of platelet aggregation in the pathogenesis
of hypertension in adult onset diabetes mellitus, 30 adult.
onset diabetic patients ( 15 hypertensives and 15 non-hypertensives)
were studied in comparison to 10 normal control subjects.
Blood sugar measurement, E.e.G, plain X-ray of the chest,
fundus.exmination, quantitative estimation of proteins in 24
hours urine; Platelet aggregation, platelet count and plasma renin
activity were done for all patients and control subjects.
Patients who had abnormal findings by fundus examination were
excluded to excluded retinopathy and patients who had proteinuria
were excluded to exclude nephropathy thus excluding the possiblity
of the present hypertension to be renal in origin.
from this study we found simultaneous increase in platelet
aggregation and plasma renin activity in both hypertensive and
non hypertensive diabetic patients when compared to normal control
subjects. Moreover, hypertensive diabetics had a significant
increase in platelet aggregation and plasma renin activity when
compared to non-hypertensive diabetics.
Our findings suggest that increased platlet aggregation
may playa role in the pathogenesis of hypertension in
diabetics via the formation of small plateletmicrothrombi
in the small renal blood vessels thus producing renal iEhemia
which stimulates renin -angiotentin system which responds by
hypersecretion of renin.
from this study we conclude that: platelet aggregation
may be increased early in adult onset diabetes mellitus irrespective
of the duration of the disease and may be involved
in the pathogenesis of hypertension occuring in adult onset
diabetic patients.
Prospective studies ~n the effect of therapeutic agents such
as asprin and dipyridamole on the natural course of diabetic
vascular disease are indncated as they may offer a protective
tool against diabetic vascular disease.
Care should be taken in the use of B-adrenoreceptor blocking
agents in treatment of hypertensive diabetic patients as they
mask hypoglycemic symptoms.
- 95 -
The role of diuretics in management of hypertensive diabetic
patients is to be re-evaluated as they may further increase
renin secretion which may be the inducer of this hypertension.